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Metronidazole has proven proof of carcinogenic action in a number of research involving Long-term oral administration in mice and rats. Distinguished amongst the results during the mouse was the marketing of pulmonary tumorigenesis. This has long been observed in all six documented research in that species, together with a person research where the animals were being dosed on an intermittent schedule (administration throughout each individual fourth 7 days only). At really high dose amounts (somewhere around 500 mg/kg/day), there was a statistically substantial increase in the incidence of malignant liver tumors in males.
Metronidazole has revealed evidence of carcinogenic action in research involving Continual oral administration in mice and rats, but not in studies involving hamsters.
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The next adverse reaction continues to be determined in the course of write-up-acceptance use of topical metronidazole. Mainly because this reaction is described voluntarily from a population of uncertain measurement, It's not normally probable to reliably estimate the frequency or build a causal relationship to drug publicity.
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